Isoamyl ester of the di-iodide of behenolic acid and process of producing same



i 20 parts being by Patented Oct. 16, 1928.

UNITED STATES PATENT OFFICE,

AUGUST WINGLER, OF ELBERFELD, NEAR COLOGNE-ON-THE-RHINE, GERMANY, A S- SIGNOR TO WINTHRO]? CHEMICAL COMPANY, INC., OF NEW YORK, N. Y.

ISOAMYL ESTER OF THE DI-IODIDE F BEHENOLIC ACID AND PROCESS OFPRODUCING SAME.

No Drawing. Application filed May 11, 1926, Serial No. 108,412, and in Germany May 12, 1925.

My invention relates to the hitherto un known ester of di-iodide of behenolic acid It isz'a useful product in medicine. It is specially suitable for subcutaneous use in View of its oily form and absence of irritation.

The process for producing the new compound consists in esterifying the di-iodide of behenolic acid or by treating with iodin or iodin furnishings substances the ester of isoamyl alcohol with behenolic acid or by treating other esters of the di-iodide of behenolic acid with isoamyl alcohol.

In order 'toillustrate my invention more fully the following example is given, the

weight One part of the di-iodide of behenolic acid is heated to 100 gether with 4 parts of isoamyl alcohol containing 4 per cent of concentrated sulfuric acid. The reactlon mass 1s shaken for several C. during several hours to- 1 times with water to remove the excess of alcohol. Subsequently the ester is dissolved in ether, the'ether is dried with Na SO and driven off. The resulting ester recrystalizes from alcohol at 0 C. It is a limpid oil solidifying at, 5-6 C.

I claim 1. The new isoamyl ester of the di-iodide of behlenolic acid having most probably the formu a which is a limpid oil solidifying at 6 C. con taining iodin and being a useful iodin preparation in medicine.

2. A process of producing the iso-amyl ester of the di-iodide of behenolic acid which comprises heating the di-iodide of behenolic acid with iso-amyl alcohol in the presence of a small amountof concentrated sulfuric acid to about 100 C. during several hours.

In testimony whereof I have hereunto set my hand.

0 AUGUST WINGLER. 

